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Recently the CXCR4/CXCL12-axis has been recognized as one of the pivotal adhesion pathways by which hematopoietic stem cells are retained in the bone marrow. CXCR4 antagonists with different chemical specification are being developed. Pharmacology research guides the...
Editeur :
Springer
Parution :
2012-02-15
ePub
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Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case...
Editeur :
Wiley
Parution :
2012-02-14
Collection :
Wiley Series on Technologies for the Pharmaceutical Industry
PDF, ePub
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The acknowledgment that viruses are potent biological factors in driving many cancers have seen a dramatic upsurge in recent years in large part to the success of the human papilloma virus vaccine against invasive cervical carcinomas and followed by the awarding of the...
Editeur :
Springer
Parution :
2012-02-14
Collection :
Current Cancer Research
ePub
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This book fulfils an urgent need for an updated text on pediatric psychopharmacology. It takes a unique approach in discussing recent findings within the context of current issues, including economic and political ones. The book covers the emerging question of treating...
Editeur :
Wiley-Blackwell
Parution :
2012-02-10
PDF, ePub
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In May of 2011, Western Europe experienced a severe outbreak of Shiga toxin (Stx)-producing E. coli (STEC) that culminated in more than 3200 cases and 39 deaths. While Stx is not the only virulence factor associated with STEC, it is certainly the primary determinant...
Editeur :
Springer
Parution :
2012-02-10
Collection :
Current Topics in Microbiology and Immunology
ePub
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This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals.This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the...
Editeur :
Wiley
Parution :
2012-02-07
PDF, ePub
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Practical drug development approaches presented by leading experts Designed to support the development of new, effective therapeutics, Topical and Transdermal Drug Delivery: Principles and Practice explains the principles underlying the field and then demonstrates how...
Editeur :
Wiley
Parution :
2012-02-03
PDF, ePub
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This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences resulting from the new European...
Editeur :
Wiley
Parution :
2012-01-27
PDF, ePub
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An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in...
Editeur :
Wiley
Parution :
2012-01-20
PDF, ePub
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Microneedles can be used for delivery of a wide range of drug substances for practically any medical condition and present a real opportunity for vaccines and medicines that are unsuitable for oral administration or conventional patch delivery. Microneedle-mediated...
Editeur :
Wiley-Blackwell
Parution :
2012-01-17
PDF, ePub
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This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal...
Editeur :
Springer
Parution :
2012-01-10
Collection :
Current Topics in Microbiology and Immunology
ePub
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Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on...
Editeur :
Wiley-Blackwell
Parution :
2012-01-09
PDF, ePub
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This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory...
Editeur :
Wiley
Parution :
2011-12-05
PDF, ePub
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This book provides an overview of critical components of cell signaling machinery and its role in epithelial morphogenesis, proliferation, invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways.
Editeur :
Springer
Parution :
2011-12-02
ePub
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Lecture Notes: Clinical Pharmacology and Therapeutics provides all the necessary information, within one short volume, to achieve a thorough understanding of how drugs work, their interaction with the body in health and disease, and how to use these drugs appropriately...
Editeur :
Wiley-Blackwell
Parution :
2011-11-28
Collection :
Lecture Notes
ePub
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This pocket reference guide is a must for all medical students and junior doctors preparing for exams in pharmacology or needing a rapid reminder during a clinical attachment. In light of the growing pressures on those who prescribe drugs to patients, increasing...
Editeur :
Wiley-Blackwell
Parution :
2011-11-28
Collection :
Rapid
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To profoundly understand biology and harness its intricacies for human benefit and the mitigation of human harm requires cross-disciplinary approaches that incorporate sophisticated computational and mathematical modeling techniques. These integrative strategies are...
Editeur :
Springer
Parution :
2011-11-23
PDF, ePub
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In recent years, increasing evidence has suggested that abnormal activation of signaling pathways is a critical event in cancer pathogenesis.In particular, activation of these pathways can lead to inappropriate cellular survival, proliferation, pluripotency, invasion,...
Editeur :
Springer
Parution :
2011-11-12
ePub
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Caveolins are important structural proteins of Caveolae, small invaginations of the membrane. They have been shown to play an important role in the pathogenesis of multiple cancers. In this volume, we will mainly focus on the importance of Caveolin-1 in breast,...
Editeur :
Springer
Parution :
2011-11-03
Collection :
Current Cancer Research
ePub
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The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of pharmacovigilance apply to...
Editeur :
Wiley-Blackwell
Parution :
2011-10-28
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