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Angiogenesis (formation of new vessels from pre-existing ones) is a crucial early event in the process of tumor development. New vessels supply the tumor with nutrients that are needed for further local growth and enable distant metastases (Folkman 1995). Judah Folkman...
Editeur :
Springer
Parution :
2010-09-02
ePub
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The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and...
Editeur :
Humana
Parution :
2010-09-02
ePub
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Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case...
Editeur :
Wiley-VCH
Parution :
2010-08-24
PDF, ePub
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Pharmaceutical and Biomedical Portfolio Management in a Changing Global Environment explores some of the critical forces at work today in the complex endeavour of pharmaceutical and medical product development. Written by experienced professionals, and including...
Editeur :
Wiley
Parution :
2010-08-03
Collection :
Wiley Series on Technologies for the Pharmaceutical Industry
PDF
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Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their...
Editeur :
Springer
Parution :
2010-07-28
Collection :
Current Cancer Research
ePub
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"Dr. Paris has written an honest, balanced presentation of the ways in which psychiatric drugs are evaluated and prescribed. He highlights the complexity of the task, the limits of what is known and the mixed picture that research often produces. His conclusions are...
Editeur :
Wiley
Parution :
2010-07-06
PDF, ePub
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The ultimate Canadian guide to prescription medication Over half of all Canadians take at least one prescription drug, but most of us know very little about the medication we're taking, including why we've been prescribed anything in the first place. Understanding...
Editeur :
For Dummies
Parution :
2010-06-28
PDF
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Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator...
Editeur :
Humana
Parution :
2010-06-16
ePub
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Energy Balance and Cancer, Epidemiology and Overview is the first in a series of monographs to address the multiple facets of the world wide pandemic of overweight and obesity and its relation to cancer. This volume, authored by leading experts in their perspective...
Editeur :
Springer
Parution :
2010-06-16
Collection :
Energy Balance and Cancer
ePub
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ExpDesign Studio facilitates more efficient clinical trial design This book introduces pharmaceutical statisticians, scientists, researchers, and others toExpDesign Studio software for classical and adaptive designs of clinical trials. It includes the Professional...
Editeur :
Wiley-Interscience
Parution :
2010-06-15
PDF, ePub
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Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980’s with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long...
Editeur :
Humana
Parution :
2010-06-10
Collection :
Current Cancer Research
ePub
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An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a...
Editeur :
Wiley
Parution :
2010-04-07
PDF
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In spite of the development of various anticancer drugs, the therapy of cancer has remained challenging for decades. The current therapy of cancer is overwhelmed because of the inability to deliver therapeutics to all regions of a tumor in effective therapeutic...
Editeur :
Humana
Parution :
2010-03-20
Collection :
Cancer Drug Discovery and Development
ePub
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Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored. In the five years...
Editeur :
Humana
Parution :
2010-03-17
Collection :
Nutrition and Health
ePub
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Although clinical trials were virtually unheard of in psychiatry for many years, they are now the gold standard for judging whether drugs are safe and useful. But should they be? What is the true status of clinical trials? Even when they ostensibly demonstrate a benefit...
Editeur :
Wiley
Parution :
2010-03-16
PDF
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Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer. This loss may occur through aberration in any single component involved in...
Editeur :
Humana
Parution :
2010-03-12
Collection :
Cancer Drug Discovery and Development
ePub
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Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with...
Editeur :
Springer
Parution :
2010-03-11
ePub
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Cancer is fundamentally a disease of abnormal cell proliferation:Cancer cells multiply when and where they should not. This proliferation entails escape from normal bounds imposed by the tissue environment, the internal biology of the cell (DNA damage, chromosomal...
Editeur :
Springer
Parution :
2010-03-10
Collection :
Current Cancer Research
ePub
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BACE inhibitors and their use in the treatment of Alzheimer's DiseaseBACE (ß-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development ofBACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for...
Editeur :
Wiley
Parution :
2010-03-05
PDF
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An expert guide to targeting protein kinases in cancer therapy Research has shown that protein kinases can instigate the formation and spread of cancer when they transmit faulty signals inside cells. Because of this fact, pharmaceutical scientists have targeted kinases...
Editeur :
Wiley
Parution :
2010-02-18
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